Single well sandstone model, porosity model and permeability model are established for the representative 7 large slope fracturing wells in Z oilfield, and the numerical simulation method for productivity of large slope fracturing well in natural fracture development reservoir of Z oilfield is formed. The numerical simulation results of different layers (S1, S3, D2, D3), different well slope angles (60 degrees, 75 degrees), different fracture parameters and production pressure difference are obtained. Through the comparison with testing data getting from exploration wells, it shows that the calculation results of numerical simulation are consistent with practical testing results, which provide a scientific basis for the prediction and analysis of large slope fracturing wells productivity in Z oilfield.